Wednesday, May 22, 2013

Fort Collins City Council lifts fracking ban on Prospect Energy

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Source: http://www.coloradoan.com/article/20130521/NEWS01/305210052/-1/rss08

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Overcoming resistance to anti-cancer drugs by targeting cell 'powerhouses'

Overcoming resistance to anti-cancer drugs by targeting cell 'powerhouses' [ Back to EurekAlert! ] Public release date: 22-May-2013
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Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Re-routing anti-cancer drugs to the "power plants" that make energy to keep cells alive is a promising but long-neglected approach to preventing emergence of the drug-resistant forms of cancer source of a serious medical problem, scientists are reporting. That's the conclusion of a new study published in the journal ACS Chemical Biology.

Shana Kelley and colleagues explain that doxorubicin and other common forms of chemotherapy work by damaging the genes inside the nucleus of cancer cells. Cancer cells divide and multiply faster than surrounding normal cells, making copies of their genes. The drugs disrupt that process. But cancer cells eventually adapt, developing structures that pump out nucleus-attacking drugs before they can work. Kelley's team explored the effects of targeting doxorubicin to the mitochondria, the energy-producing structures in cells that also contain genes.

They describe a re-targeting approach that involved mating doxorubicin with a small piece of protein that made the drug travel to mitochondria instead of the nucleus. The combo killed cancer cells, even those that had developed pumps. Such an approach could work with a whole family of anti-cancer drugs that target the nucleus, the scientists indicate.

###

The authors acknowledge funding from the Canadian Institutes of Health Research.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

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Overcoming resistance to anti-cancer drugs by targeting cell 'powerhouses' [ Back to EurekAlert! ] Public release date: 22-May-2013
[ | E-mail | Share Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Re-routing anti-cancer drugs to the "power plants" that make energy to keep cells alive is a promising but long-neglected approach to preventing emergence of the drug-resistant forms of cancer source of a serious medical problem, scientists are reporting. That's the conclusion of a new study published in the journal ACS Chemical Biology.

Shana Kelley and colleagues explain that doxorubicin and other common forms of chemotherapy work by damaging the genes inside the nucleus of cancer cells. Cancer cells divide and multiply faster than surrounding normal cells, making copies of their genes. The drugs disrupt that process. But cancer cells eventually adapt, developing structures that pump out nucleus-attacking drugs before they can work. Kelley's team explored the effects of targeting doxorubicin to the mitochondria, the energy-producing structures in cells that also contain genes.

They describe a re-targeting approach that involved mating doxorubicin with a small piece of protein that made the drug travel to mitochondria instead of the nucleus. The combo killed cancer cells, even those that had developed pumps. Such an approach could work with a whole family of anti-cancer drugs that target the nucleus, the scientists indicate.

###

The authors acknowledge funding from the Canadian Institutes of Health Research.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter Facebook


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/acs-ort052213.php

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Internet Marketing Promotion For Small Business, Website, Events ...

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Source: http://www.rangrage.com/internet-marketing-promotion-for-small-business-website-events-social-media/

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Jackson County will also pay more for flood insurance, leaders say ...

PASCAGOULA, Mississippi -- Jackson County will not be exempt from the changes causing higher costs for National Flood Insurance Program policies, supervisors said this morning.

The Biggert-Waters Act, which was meant to overhaul the in-debt program and make it self-sufficient, was signed into law last July.

The act ends flood insurance subsidies to homeowners by 2014 and generally increases premiums as flood insurance risk maps are updated.

The new rates are meant to reflect true flood risk, but many have argued the price hikes will devastate property owners. There's a national debate over how to handle the increases, with some suggesting the hikes be pushed back.

Jackson County Supervisor Mike Mangum, board president, asked county staff this morning if the county would be affected.

County Administrator Brian Fulton told him it would.

"Everybody's flood insurance is going to increase," Fulton said, especially those in special hazard zones.

"It's my knowledge that we don't have many of those properties owned by the county," he said, so the county's impact should be less significant.

The county's new general services complex building in Pascagoula shouldn't see too much of an increase "because of the way we built it," Supervisor Jon McKay noted. "But everything is going to go up, no doubt about that."

Also at Monday's meeting, supervisors:

  • Refunded 2 bonds from 2005 at a lower interest rate to save about $275,000 over the life of the bonds.
  • Accepted Kennedy Lane as a county road in District 1.
  • Commissioned Dennis Seymour and Ian Pehnke into the sheriff's reserves.

Source: http://blog.gulflive.com/mississippi-press-news/2013/05/jackson_county_will_also_pay_m.html

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Tuesday, May 21, 2013

Teen?s device charges a phone in 20 seconds



>>> finally we've all been there. how about this, somewhere like here in hawaii and look down and only got one bar of batteries left on your cell phone . well if you're looking for a faster way to charge cell phones , the long wait may be over. apparently we've got an invention from an 18-year-old high school student from california, her name is eisha carr and she won $50,000 in an international science fair for inventing an energy storage device that fully charges in about 20 seconds. she calls it a super capacitor , and she has attracted the attention of google, apparently they've been in contact with her about that invention. maybe they'll pay her $1 billion something.

>> that's unbelievable. good for her.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2c2872b7/l/0Lvideo0Btoday0Bmsnbc0Bmsn0N0Cid0C51938889/story01.htm

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AP Photos: Images of devastating Oklahoma tornado

AAA??May. 20, 2013?11:29 PM ET
AP Photos: Images of devastating Oklahoma tornado
By The Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?By The Associated Press

This aerial photo shows the remains of houses in Moore, Okla., following a tornado Monday, May 20, 2013. A tornado roared through the Oklahoma City suburbs Monday, flattening entire neighborhoods, setting buildings on fire and landing a direct blow on an elementary school. (AP Photo/Steve Gooch)

This aerial photo shows the remains of houses in Moore, Okla., following a tornado Monday, May 20, 2013. A tornado roared through the Oklahoma City suburbs Monday, flattening entire neighborhoods, setting buildings on fire and landing a direct blow on an elementary school. (AP Photo/Steve Gooch)

Glenn Rusk hugs his neighbor Sherie Loman outside her home north of Briarwood Elementary School after a tornado moved through the area, in Moore, Okla., Monday, May 20, 2013. (AP Photo/The Oklahoman, David McDaniel)

A woman carries a child through a field near the collapsed Plaza Towers Elementary School in Moore, Okla., Monday, May 20, 2013. The relationship between the woman and the child was not immediately known. A tornado as much as a mile (1.6 kilometers) wide with winds up to 200 mph (320 kph) roared through the Oklahoma City suburbs Monday, flattening entire neighborhoods, setting buildings on fire and landing a direct blow on an elementary school. (AP Photo Sue Ogrocki)

JoAnn Anderson sorts through the rubble of her home after a tornado on Monday, May 20, 2013 in Moore, Okla. A monstrous tornado roared through the Oklahoma City suburbs, flattening entire neighborhoods with winds up to 200 mph, setting buildings on fire and landing a direct blow on an elementary school. (AP Photo/The Oklahoman, Steve Sisney)

Teachers carry children away from Briarwood Elementary school after a tornado destroyed the school in south Oklahoma City, Monday, May 20, 2013. A monstrous tornado roared through the Oklahoma City suburbs, flattening entire neighborhoods with winds up to 200 mph, setting buildings on fire and landing a direct blow on an elementary school. (AP Photo/The Oklahoman, Paul Hellstern)

The devastating tornado that swept through Oklahoma turned houses into matchsticks and sent parents and teachers running to pull children from the wreckage of an elementary school in the eye of the storm. At least 51 people were killed by the 200-mph storm and dozens of homes destroyed. The toll was expected to rise. Here are images from the aftermath :

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-20-Oklahoma%20Tornado-Photo%20Gallery/id-dc11dbd5ce1b4d93b7fac9da8c8468f0

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Portland Fluoridation Vote Reignites Debate

Voters in Portland, Ore., will decide tomorrow (May 21) whether the city will begin fluoridating its water. For weeks, residents have been contentiously debating water fluoridation, the addition of fluoride to public water supplies for the purpose of reducing cavities and tooth decay.

Portland is one of the largest metropolitan areas in the United States that doesn't add fluoride to public drinking water supplies. Currently, two-thirds of Americans have fluoridated public water, according to the Centers for Disease Control and Prevention (CDC).

The debate has split the relatively liberal city, causing a "civil war amongst progressives," as the Oregonian put it. Pro-fluoride groups say that fluoridation will help reduce cavities among poor children who don't have access to dental care. Those in the opposing camp object to fluoridation's possible negative health effects, like impaired brain development and function, and say the practice amounts to forced medication of the populace without consent.

If Portland voters decide to keep fluoride out of their water, it would be the fourth time since the 1950s that the city has rejected it, according to government records. That makes it unique amongst large American cities, most of which have implemented it.

The groups against fluoridation include the local union representing Oregon Department of Environmental Quality employees, and the local chapter of the Sierra Club, which has said fluoridation would endanger the health of rivers, wildlife and people.

Portland's chapter of the NAACP has also voted to oppose the measure. "Children growing up in communities of color already face risks from many different environmental chemicals, and they do not need more chemicals added to their drinking water," NAACP political chair Cheryl Carter told Willamette Week, a local publication.

Fluoridation is supported by the American Medical Association, the American Dental Association and the CDC, which lists it as one of the top 10 most important public health measures of the 20th century. It is also supported by dental and medical groups such as Kaiser Permanente and the Oregon Dental Association, as well as several groups that represent people of color and low-income communities, according to Slate.

Groups on both sides have spent money on ads and fliers that have been distributed around the city. Pro-fluoridation groups have a lot more funds than their opponents. As of May 20, the main fluoridating group, Healthy Kids, Healthy Portland, had received $845,870.45. The main anti-fluoridation group, Clean Water Portland, got less than one-third of that, at $269,439.09, according to the Oregon Secretary of State.

A poll of likely voters conducted on May 16, by local ABC News affiliate KATU-TV, found a 13-percentage point lead among those against fluoridation. However, "in a low-turnout election, any outcome remains possible," the station noted.

Fluoridation began on a small scale in the 1940s in Grand Rapids, Mich., and later in towns in New York State. It caused a fair amount of debate about its effectiveness and possible health effects in the 1950s and 1960s, but the arguments faded from the national conversation as the process garnered the support of most large medical and dental groups.

Tooth decay, when left untreated, can lead to serious health problems, such as infections that can spread into the jaw. Tooth decay has declined in the United States since fluoridation began; however, it has also declined in other countries that do not fluoridate, said William Hirzy, a chemist at American University who worked at the Environmental Protection Agency for 27 years before leaving in 2008.

A 2009 study that tracked fluoride consumption and exposure in more than 600 Iowan children found no significant link between fluoride exposure and tooth decay, said Kathleen Thiessen, a scientist at SENES Oak Ridge Inc., an environmental risk-assessment company.

Americans are now exposed to many more sources of fluoride than when the practice of fluoridation began, Hirzy told LiveScience. Until about the year 2000, it wasn't widely acknowledged by the public health community that fluoride primarily works topically. That means there is no benefit to swallowing it and exposing your whole body to the substance, said Hirzy, who is opposed to fluoridation.

And while the issue remains contentious, new evidence suggests that fluoride could be linked to unforeseen health effects at concentrations nearing those put into water. Studies have linked fluoride exposure to bone fractures, thyroid disorders and certain cancers, according to a report by the National Research Council in 2006.

One study published last fall in the journal Environmental Health Perspectives found a link between high fluoride levels found naturally in drinking water in China and elsewhere in the world, and lower IQs in children. The paper looked at the results of 27 different studies, 26 of which found a link between high-fluoride drinking water and lower IQ. The average IQ difference between high and low fluoride areas was 7 points, the study found. ?

However, most of the drinking water in these studies contained fluoride at concentrations several times greater than the level at which it is added to fluoridated water in the United States, where it averages about 1 part per million (ppm). But several of the studies found lower intelligence scores in kids drinking water with only three times more fluoride than is found in fluoridated U.S. water.

Harvard researcher Philippe Grandjean, lead author of the study, wrote in an email to LiveScience that his results "do not allow us to make any judgment regarding possible levels of risk at levels of exposure typical for water fluoridation in the U.S. On the other hand, neither can it be concluded that no risk is present."

But Hirzy told LiveScience that a threefold difference between the levels in U.S. water and the level that may be linked with damage is not enough to protect children. These exposure levels overlap, in part because some kids drink a lot of water. There should ideally be at least a tenfold, and preferably a hundredfold, difference between the levels at which no adverse health effects can be demonstrated, and the so-called "safe" level, he said.

The National Research Council's 2006 report found that the Environmental Protection Agency's upper limit for fluoride, at 4 ppm, was too high to prevent a certain percentage of kids from developing severe dental fluorosis, a condition in which teeth are stained and pitted.

However, Grandjean compared fluoride to other chemicals discussed in his book published this month called "Only One Chance: How Environmental Pollution Impairs Brain Development ? and How to Protect the Brains of the Next Generation."

"When researching for my book, it was clear that fluoride was no different from other chemicals," he wrote. "The potential for adverse effects on brain development has been ignored for many, many years."?Grandjean reiterated, however, that he did not want to take a stance on water fluoridation, and that the point of his book was more general: "We must protect brain development in the next generation," he said.?

Many people don't realize that fluoride in fluoridated water comes not from the fluoride salts used in dental products, but from silicofluorides, which "are one of the by-products from the manufacture of phosphate fertilizers," according to the National Research Council's 2006 report.

"The toxicity database on silicofluorides is sparse and questions have been raised about the assumption that they completely dissociate in water and, therefore, have toxicity similar to the fluoride salts tested in laboratory studies and used in consumer products," the report noted.

Email Douglas Main?or follow him @Douglas_Main. Follow us @livescience, Facebook?or ?Google+. Article originally on?LiveScience.com .

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/portland-fluoridation-vote-reignites-debate-212426791.html

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Featured Fitale Georgina Graham | Femme Fitale? Fit Club Blog

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FFFC:? Please introduce yourself to our readers (i.e. your name, occupation, hobbies, etc.).

GG:? Good Day! My name is Georgina Graham.? By day I am an aviation expert, acting as an advocate and promoting excellence in safety, security and environmental?issues in Civil Aviation.? By night,I am a shoe-loving, time-travelling scribbler with a passion for fitness and helping others achieve their goals and their dreams.? I am currently transitioning location (from Canada) to the United Kingdom and starting my own Coaching Consultancy ~ Be Utterfly Fly Fitness.

FFFC:? What sparked your weight-loss transformation journey?

GG:? I was tired. Tired of not liking how I looked on the outside or felt? on the inside.? Tired of feeling like the REAL me was hidden inside, underneath the nice clothes, high heels (always!), make up and hair.? I wanted to feel free of the burden of weight ? which was really an outward manifestation of the fact I did not care enough about myself to put myself first.

FFFC:? What was your beginning and current weight or measurements?

GG:? At my heaviest, I had stopped really weighing myself.? My heaviest recorded weight was? 227 lbs.? I currently have just finished a (not too clean!) off-season Bulk for
competitive body-building and I weigh 170 lb.? My usual?weight is around 155 lbs.? My ?stage? weight? is about 135-140.? I still have two wardrobes!? Off season and on!? I am probably at the heaviest weight I have been since reaching my goal weight ? but I love my body every which way. You can only get the body you want by loving the body you have!

FFFC:? How long did it take for your weight-loss transformation from beginning to end?

GG:? I took about 6 months to reach my goal weight.? Then I adjusted the goal down in order to compete and I lost a further 20 lbs while also maintaining lean muscle in order to step on stage.? Each person?s journey is their own to complete in a healthy way ? usually losing no more than 1lb-2lbs per week is the healthiest route for sustainable weight
loss.

FFFC:? What physical activities did you participate in during your journey?

GG:? I used Fitness DVD?s at home 6 days a week? These included cardio kickboxing, plyometrics, kenpo and strength training? I also made sure to walk 10,000 steps a day, so being active even if not actually working out.

FFFC:? How did your eating habits change??

GG:? I actually STARTED eating.? Prior to my transformation, I would eat once a day.? I was so busy being ?busy? with work, I would keep putting off meal after meal, until after working up to a 15 hour day I was too tired to cook, so would just have something like a bagel with cheese.? Little did I realize at the time how much I was damaging my metabolism.? At the beginning of my transformation, I would set an alarm to eat every two hours, until my body reacted without the reminder.? I then started to prepare my meals in advance and take lunch to work every day plus snacks.? I would eat 5-6 meals a day.? I also made sure to drink a gallon of water every day.

FFFC:? What do you typically eat for breakfast, lunch and dinner?

GG:? I am pretty much a? creature of habit until you tell me I can?t have something!? This would be a meal plan outside of competition training -?For Breakfast I usually?have oatmeal and egg whites, or an omelette made with a whole egg and some egg whites, red onions, mushrooms and some chicken bacon.? Some days I may have just Whole eggs with some veggies, probably spinach. I also love Kale based smoothies (but try not to cook it slightly first so it does not interfere with my thyroid function).? I would add in some almond milk, coconut oil and maybe some blueberries, strawberries or half a banana.? Around 10am I have a protein shake or some almonds and an apple, or rice cakes with almond butter.? Lunch would also be some protein with a green salad made with say, spinach, cucumber, avocado, romaine lettuce or veg and some sweet potato or brown rice. In the early evening I would have my dinner before training, and this would be some form of lean protein ? chicken breast, turkey, tilapia, or salmon or lean steak or lentils along with veggies, or a salad or quinoa, or other types of
beans.??Immediately after training I would have a protein shake with a simple carbohydrate, to help cause an insulin spike to take the protein straight to the muscles which I have just DESTROYED!

FFFC:? What is your favorite fitness activity?

GG:? LIFTING WEIGHTS!!

FFFC:? What do you do now to maintain your physique?

GG:? TRAIN, EAT, SLEEP!? I was prevented from competing last year due to a thyroid issue and allowing life to get in the way.? My view now is that health is the best wealth we have.? Competition training and dieting is pretty brutal, so you have to be clear in your mind of your goals and your values, so as not to compromise yourself in search of a particular aesthetic that is impossible to maintain.? My aim is to train hard, but maintain the health balance at the same time.? If this prevents me from stepping on the stage this year, then so be it.? I have days when I do crave something that may not be in my best interests to eat, and I am no Saint. So I do everything in moderation ? and with intent.? The worse feeling is the one where you are being controlled either by the presence or absence of something.

My Journey

FFFC:? How did you develop and sustain the willpower to avoid the bad stuff (i.e. junk food, bad drinks, lack of activity, etc.)?

GG:? You have to make sure your WHY is stronger than your WON?T.? Effectively, willpower is a muscle like any other.? The more you use it the stronger it becomes.? To me, the whole weight loss journey is one of mind over matter.? Getting up to train at What O?Clock in the morning when there is 5 inches of snow on the ground and it is minus a bazillion degrees is no fun.? Wanting to go home after a long day at work but not and going to the gym instead all takes discipline -? doing what needs to be done, not what you want to do.? I do slip up, and life can knock you down, and sometimes of late after one too many ?body blows? I have felt like I wanted to stay down, but in the end, I never give up.? I try to make mindful choices so that whatever the outcome, it was by choice not by chance.? My faith also keeps me focused and only by the Grace of God am I here today.

FFFC:? What advice do you have for someone starting out on their weight-loss journey but unsure of how to begin?

GG:? Make small, CONSISTENT changes.? Over time, these changes will add up to success.? Throw away the scale and prepare your environment to support your goals.? Establish a vision for yourself, not someone else?s idea of how you should look or what you should eat.? One thing you will probably find on your own journey is that some people will be inspired, others will be threatened.? Some may try to derail you, so it is important that the voice that resonates most loudly in your head is your own.? Don?t be swayed by praise (thinking you can add in some treats) or by criticism (thinking you should?just stop).?? I think, depending on the type of personality you have, factoring in something that might be considered a treat is important.? Feeling deprived is the easiest way to slip back into bad habits. But it is all amount making good choices.? For instance, I love to eat chocolate, milk chocolate to be precise!? Instead of that, which is really just sugar, I have no learned to like dark chocolate.? I only need a few pieces in order to satisfy that craving and then I am good.? I love a glass of red wine occasionally and some healthy popcorn as a snack.? Even if I over do it on any one day, there is always the next meal, there is always tomorrow, because that is what life is about.? It doesn?t have to be all or nothing.? Looking at this as a long-term, lifestyle change is important too ? there is no end.? It really can?t be perceived as a diet.? Mostly, your MIND has to be in the right place in order to maintain your physique.? Our external self is a reflection of our internal, so spend as much time working on your mind as your body.

FFFC:? What do you think is the biggest misconception about this journey?

GG:? The biggest misconception is that only certain people can do it.? Anyone can do it!? Success does not come over night, and many people believe if they eat right and train for a week or two, but they don?t see any meaningful changes, they should give up.? DIETS do not work! The Diet industry would?not be an industry otherwise.? So really think of this as a lifestyle change, day by day, and results will come.? There is no such thing as a quick fix.? Whether it?s ten minute abs, lose 10 lbs?in one day, take this pill or drink this drink.? In the end it boils down to what you eat and when and what exercise you do, creating a deficit between what you eat (fuel) and what you expend.? Understanding that the choices you make today make the body you have tomorrow.

FFFC:? Do you have any fitness idols?? Who are they?

GG:? I have some women who have trodden this path before me and encouraged me on my way.? Women who were willing to share with me their own ups and downs and their
own knowledge.? These women paid their blessings forward and for that I will always be grateful.? In terms of well known fitness personalities -? I admire people like Florence Griffiths-Joyner and Lenda Murray ? women that raised the bar, yet maintained class and dignity and then pulled many up behind them.? Also, men like Charles Poliquin and John Beradi who have used their knowledge of the fitness industry, nutrition and training techniques to change how people perceive those in the industry, by using a scientific approach to training and
nutrition.

FFFC:? How can readers learn more about your transformation and journey online (i.e. Facebook, Tumblr, Twitter, etc.)?

GG:? I started my Facebook Page ? Be Utterly Fly Fitness ? in January 2013, with the aim to build a movement of EMPOWERED people, who are FIT in body, mind and soul ? who gain their wings to be FLY (Fit Limitless You).? That is located at www.facebook.com/BeFlyToo.? I will be launching an on-line radio program in the near future to share Fitness, Food and Focus ? so you can follow me at www.blogtalkradio.com/BuffButterfly.? Tweet me @BeUtterfly and watch this space for the launch of my website www.BuffButterfly.com.? If you want to contact me by email, then please feel free to do so at coach@BuffButterfly.com? Thank you so much for your interest and thank you Diatta for giving me this truly awesome opportunity.? I am humbled and I pray that I will be able to continue to serve those who are in need!

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? Georgina Graham 2013

Femme Fitale Fit Club

Motivating you to Firm, Fit and Fabulous!

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Source: http://femmefitaleblog.com/2013/05/20/featured-fitale-georgina-graham/

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Monday, May 20, 2013

Boychuk breaks Game 2 tie, Bruins top Rangers 5-2

New York Rangers right wing Ryan Callahan (24) celebrates his goal and center Derek Stepan cheers from behind as Boston Bruins defenseman Zdeno Chara (33) reacts during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

New York Rangers right wing Ryan Callahan (24) celebrates his goal and center Derek Stepan cheers from behind as Boston Bruins defenseman Zdeno Chara (33) reacts during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

New York Rangers center Brian Boyle (22) goes down to the ice as he chases the puck against Boston Bruins defensemen Adam McQuaid (54) and Torey Krug (47) during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

Boston Bruins defenseman Matt Bartkowski (43) and New York Rangers right wing Ryan Callahan (24) grapple along the boards during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

New York Rangers right wing Ryan Callahan, left, scores against Boston Bruins goalie Tuukka Rask, right, during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

Boston Bruins defenseman Zdeno Chara, front left, goes down against New York Rangers right wing Ryan Callahan (24) as Bruins left wing Daniel Paille (20) looks on during the first period in Game 2 of the NHL Eastern Conference semifinal hockey playoff series in Boston, Sunday, May 19, 2013. (AP Photo/Elise Amendola)

(AP) ? Claude Julien wanted his Bruins to play more aggressively in the third period. The Boston coach got his wish with the help of some shaky defense by the New York Rangers.

A rare rough day for goalie Henrik Lundqvist certainly helped, too.

Brad Marchand and Milan Lucic scored in the final period after Johnny Boychuk broke a tie in the second, Lundqvist gave up more than four goals for the first time in 152 games, and Boston beat New York 5-2 on Sunday to take a 2-0 lead in the Eastern Conference semifinal series.

"Some games you're going to get more goals, some maybe less," Bruins captain Zdeno Chara said, "but the important thing was we were trying to focus on playing hard until the end."

New York's best period was the second when it outshot Boston 16-9. The Rangers then allowed two goals in the third.

"We gave it to them," said Lundqvist, last year's Vezina Trophy winner as the NHL's top goalie. "I thought we played great. I didn't think they had to work really hard to get a couple goals there. We just made it really tough on ourselves."

Games 3 and 4 in the best-of-seven series will be played in New York on Tuesday and Thursday nights.

The Rangers played their best period of the series in the second, but Brad Marchand gave Boston a 4-2 lead just 26 seconds into the third.

Patrice Bergeron carried the puck in deep on the right side and passed across the crease to Marchand, who had gotten behind defenseman Dan Girardi for a tip-in.

"We felt really good going into the third, and to have that type of goal go in ? it's just two-on-two ? it hurts you," Rangers coach John Tortorella said. "We couldn't generate anything, and then they're just going to fill the middle and they're just going to jam you."

The Bruins went ahead to stay, 3-2, at 12:08 of the second period when Boychuk, who had one goal in the regular season, shot a 40-footer inside the near post for his third playoff goal.

The shot got through several players before it sailed past Lundqvist.

"It was definitely a screen," Boychuk said. "All I had to do was hit the net because there were a couple of guys in front of him."

Boston never trailed as rookie Torey Krug scored the first goal before Rangers captain Ryan Callahan tied it. Gregory Campbell made it 2-1, and New York pulled even again on Rick Nash's goal, his first of the playoffs after he led the Rangers with 21 in the regular season.

Now the Rangers find themselves in a familiar position, down 0-2.

They lost the first two games of their first-round series in Washington, won the next two in New York before losing Game 5 on the road.

But Lundqvist posted consecutive shutouts in Games 6 and 7 against the Capitals when the Rangers faced elimination.

"We've done it before," Lundqvist said, "but I think we are playing a better team now so it's going to be tough to do it."

There's also the matter of his left shoulder that was hit by Daniel Paille's shot in the third period. Lundqvist rubbed it after the game and said, "We'll take a look at it."

Tuukka Rask was solid again for Boston, stopping 35 shots.

"You have to give Tuukka a lot of credit," Julien said. "Turnovers and giveaways in the second period are not something we do too much, and it could have been disastrous."

After the second period, "I told guys to play to win," he said. "I don't like our team when we are back on our heels and protecting a one-goal lead that way."

Marchand gave the Bruins a two-goal advantage when he scored on a play just like the one that gave Boston a 3-2 overtime win on Thursday night.

"It was very similar. I was kind of hanging back there backdoor, and Bergy made an unbelievable pass again," he said. "It's always good to get a couple-goal lead early in the third."

Lucic made it 5-2 at 12:39. He skated into the New York end and gave the puck to David Krejci, who was stopped by Lundqvist, but Lucic converted the rebound.

The last time Lundqvist allowed more than four goals was March 9, 2011, in a 5-2 loss to Anaheim. In the next 151 games, in the regular season and playoffs, he allowed four goals just 13 times.

Tortorella remains confident despite the five goals Lundqvist gave up Sunday

"I don't need to evaluate Henrik," he said. "We know what Henrik is."

It takes more than consecutive losses to rattle Lundqvist.

"I'm confident I'm going to go home and try to play a strong game in the next one," he said.

After a series in which the teams were basically even throughout the first game and the first two periods of the second, the Bruins aren't overconfident.

"We didn't play our best," Marchand said. "They had a lot of opportunities that if they would've converted on, then it would be a completely different story right now. I think especially in the second period, they took it to us, but we were able to bounce back. It's definitely a very even series."

NOTES: Lundqvist has started New York's last 29 games against Boston. ... The Bruins played their second straight game without injured veteran defensemen Andrew Ference, Dennis Seidenberg and Wade Redden. ... A Bruins defenseman got a goal or an assist on each of the team's goals. ... The margin of victory was more than two goals for just the second time in 26 games between the Rangers and Bruins. ... In their nine playoff games, the Rangers have scored just twice on 35 power plays. They are 0-for-7 against the Bruins.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-19-HKN-Rangers-Bruins/id-2d963e9ac5824f73b2dbd211e56f7e28

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Immune protein could stop diabetes in its tracks

Immune protein could stop diabetes in its tracks [ Back to EurekAlert! ] Public release date: 19-May-2013
[ | E-mail | Share Share ]

Contact: Liz Williams
williams@wehi.edu.au
61-405-279-095
Walter and Eliza Hall Institute

Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis.

Professor Len Harrison, Dr Esther Bandala-Sanchez and Dr Yuxia Zhang led the research team from the Walter and Eliza Hall Institute that identified the immune protein CD52 as responsible for suppressing the immune response, and its potential for protecting against autoimmune diseases. The research was published today in the journal Nature Immunology.

So-called autoimmune diseases develop when the immune system goes awry and attacks the body's own tissues. Professor Harrison said CD52 held great promise as a therapeutic agent for preventing and treating autoimmune diseases such as type 1 diabetes.

"Immune suppression by CD52 is a previously undiscovered mechanism that the body uses to regulate itself, and protect itself against excessive or damaging immune responses," Professor Harrison said. "We are excited about the prospect of developing this discovery to clinical trials as soon as possible, to see if CD52 can be used to prevent and treat type 1 diabetes and other autoimmune diseases. This has already elicited interest from pharmaceutical companies."

Type 1 diabetes is an autoimmune disease that develops when immune cells attack and destroy insulin-producing beta cells in the pancreas. Approximately 120,000 Australians have type 1 diabetes and incidence has doubled in the last 20 years. "Type 1 diabetes is a life-long disease," Professor Harrison said. "It typically develops in children and teenagers, and it really makes life incredibly difficult for them and their families. It also causes significant long-term complications involving the eyes, kidneys and blood vessel damage, and at great cost to the community."

Professor Harrison said that T cells that have or release high levels of CD52 are necessary to maintain normal balance in the immune system. "In a preclinical model of type 1 diabetes, we showed that removal of CD52-producing immune cells led to rapid development of diabetes. We think that cells that release CD52 are essential to prevent the development of autoiummune disease, and that CD52 has great potential as a therapeutic agent," he said.

CD52 appears to play a dominant role in controlling or suppressing immune activity in the early stages of the immune response, Professor Harrison said. "We identified a specialised population of immune cells (T cells) that carry high levels of CD52, which they release to dampen the activity of other T cells and prevent uncontrolled immune responses," Professor Harrison said. "The cells act as an early 'braking' mechanism."

Professor Harrison said his goal is to prevent and ultimately cure type 1 diabetes. "In animal models we can prevent and cure type 1 diabetes," Professor Harrison said. "I am hopeful that these results will be translatable into humans, hopefully in the not-too-distant future."

###

The research was supported by the National Health and Medical Research Council of Australia and the Victorian Government.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Immune protein could stop diabetes in its tracks [ Back to EurekAlert! ] Public release date: 19-May-2013
[ | E-mail | Share Share ]

Contact: Liz Williams
williams@wehi.edu.au
61-405-279-095
Walter and Eliza Hall Institute

Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis.

Professor Len Harrison, Dr Esther Bandala-Sanchez and Dr Yuxia Zhang led the research team from the Walter and Eliza Hall Institute that identified the immune protein CD52 as responsible for suppressing the immune response, and its potential for protecting against autoimmune diseases. The research was published today in the journal Nature Immunology.

So-called autoimmune diseases develop when the immune system goes awry and attacks the body's own tissues. Professor Harrison said CD52 held great promise as a therapeutic agent for preventing and treating autoimmune diseases such as type 1 diabetes.

"Immune suppression by CD52 is a previously undiscovered mechanism that the body uses to regulate itself, and protect itself against excessive or damaging immune responses," Professor Harrison said. "We are excited about the prospect of developing this discovery to clinical trials as soon as possible, to see if CD52 can be used to prevent and treat type 1 diabetes and other autoimmune diseases. This has already elicited interest from pharmaceutical companies."

Type 1 diabetes is an autoimmune disease that develops when immune cells attack and destroy insulin-producing beta cells in the pancreas. Approximately 120,000 Australians have type 1 diabetes and incidence has doubled in the last 20 years. "Type 1 diabetes is a life-long disease," Professor Harrison said. "It typically develops in children and teenagers, and it really makes life incredibly difficult for them and their families. It also causes significant long-term complications involving the eyes, kidneys and blood vessel damage, and at great cost to the community."

Professor Harrison said that T cells that have or release high levels of CD52 are necessary to maintain normal balance in the immune system. "In a preclinical model of type 1 diabetes, we showed that removal of CD52-producing immune cells led to rapid development of diabetes. We think that cells that release CD52 are essential to prevent the development of autoiummune disease, and that CD52 has great potential as a therapeutic agent," he said.

CD52 appears to play a dominant role in controlling or suppressing immune activity in the early stages of the immune response, Professor Harrison said. "We identified a specialised population of immune cells (T cells) that carry high levels of CD52, which they release to dampen the activity of other T cells and prevent uncontrolled immune responses," Professor Harrison said. "The cells act as an early 'braking' mechanism."

Professor Harrison said his goal is to prevent and ultimately cure type 1 diabetes. "In animal models we can prevent and cure type 1 diabetes," Professor Harrison said. "I am hopeful that these results will be translatable into humans, hopefully in the not-too-distant future."

###

The research was supported by the National Health and Medical Research Council of Australia and the Victorian Government.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/waeh-ipc051813.php

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Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria

May 18, 2013 ? In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as staphylococci (Staphylococcus aureus).

Antibiotic-resistant bacteria is a huge problem all over the world: For example, 25 -- 50 per cent of the inhabitants in southern Europe are resistant to staphylococci. In the Scandinavian countries it is less than 5 per cent, but also here the risk of resistance is on the rise.

So any effective anti-inflammatory candidate is important to investigate -- even if the candidate is an antipsychotic that was originally developed to alleviate one of the hardest mental illnesses, schizophrenia.

Until now, scientists could only see that thioridazine works effectively and that it can kill staphylococcus bacteria in a flask in the laboratory, but now a new study reveals why and how thioridazine works. The research group, which includes professor Hans J?rn Kolmos, associate professor Birgitte H. Kallipolitis and other participants from the Department of Biochemistry and Molecular Biology and Institute of Clinical Medicine, University of Southern Denmark, publishes their findings in the journal PLOS ONE on May 17 2013.

The research team tested thioridazine on staphylococcal bacteria and discovered that thioridazine works by weakening the bacterial cell wall.

"When we treat the bacteria with antibiotics alone, nothing happens -- the bacteria are not even affected. But when we add both thioridazine and antibiotics, something happens: thioridazine weakens the bacterial cell wall by removing glycine (an amino acid) from the cell wall. In the absence of glycine, the antibiotics can attack the weakened cell wall and kill staphylococcus bacteria," explains Janne Kudsk Klitgaard, visiting scholar at the Department of Biochemistry and Molecular Biology, University of Southern Denmark.

Thus, it is the interaction between thioridazine and antibiotic that works.

And now that researchers know that thioridazine works by weakening staphylococcal cell wall, they can concentrate on improving this ability.

"Now that we know how thioridazine works, we can develop drugs that target the resistant bacteria. And just as important: We can remove or inactivate the parts of thioridazine, which treats schizophrenia, so we end up with a brand new product that is no longer an antipsychotic, "explains Janne Kudsk Klitgaard.

According to her, we are now a little closer to a safe, non-psychopharmacological drug that can save people from potentially fatal infections that do not respond to antibiotics.

"This will no longer be an antipsychotic, when scientists are finished with this task," she says.

Together with her colleagues Klitgaard tested thioridazine on roundworms in the laboratory and have seen that they were cured of staphylococci in the gut. Next step will be testing on mice and pigs.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/KHZgMZHOdQs/130518153742.htm

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Probe into Conn. train crash giving way to cleanup

BRIDGEPORT, Conn. (AP) ? Investigators will look closely at a broken section of rail to see if it is connected to the commuter train derailment and collision outside New York City that left dozens injured, as the focus begins to shift toward cleanup and rebuilding ahead of challenging times for travelers and commuters along the Northeast Corridor.

A member of the National Transportation and Safety Board said Saturday that a fractured section of rail is of substantial interest to investigators and a portion of the track will be sent to a lab for analysis. Officials also said Saturday the incident was not the result of foul play.

It's not clear if the accident caused the fracture or if the rail was broken before the crash, the NTSB's Earl Weener said. He emphasized the investigation was in its early stages and said he won't speculate on the cause of the derailment. Data recorders on board are expected to provide the speed of the Metro-North trains at the time of the crash and other information, he said.

Seventy-two people were sent to the hospital Friday evening after a Metro-North train heading east from New York City derailed and was hit by a train heading west from New Haven. Most have been discharged.

Officials earlier described devastating damage and said it was fortunate no one was killed.

"I feel that we are fortunate that even more injuries were not the result of this very tragic and unfortunate accident," said U.S. Sen. Richard Blumenthal, who visited several patients in the hospital.

The crash damaged the tracks and threatened to snarl travel in the Northeast. The crash also caused Amtrak to suspend service between New York and Boston.

Blumenthal called the damage "absolutely staggering,"

Attention is slowly shifting to the cleanup, restoration ? and the upcoming work week.

Metro-North said train service will remain suspended between South Norwalk and New Haven until further notice. Railroad officials said rebuilding the two tracks and restoring train service "will take well into next week."

NTSB investigators arrived Saturday and are expected to be on site for seven to 10 days. They'll look at the brakes and performance of the trains, the condition of the tracks, crew performance and train signal information, among other things.

When the NTSB concludes the on-site phase of its investigation, Metro-North will begin to remove the damaged rail cars and remaining debris. The process requires specialized, heavy equipment that was expected to be in place Sunday, officials said. Only after the damaged train cars have been removed can Metro-North begin the work of rebuilding the damaged tracks and overhead wires.

"It is a significant undertaking that could take days to complete," MTA said in a statement.

The NTSB has allowed Metro-North to begin removing some of the track and wire from the scene.

Gov. Dannel P. Malloy said commuters should make plans for alternative travel through the area and urged them to consult the state Department of Transportation website for information.

Bridgeport Mayor Bill Finch said the disruption caused by the crash could cost the region's economy millions of dollars.

About 700 people were on board the Metro-North trains when one heading east from New York City's Grand Central Terminal to New Haven derailed at about 6:10 p.m. just outside Bridgeport, transit and Bridgeport officials said. Passengers described a chaotic, terrifying scene of crunching metal and flying bodies.

A spokeswoman for St. Vincent Medical Center said late Saturday that 46 people from the crash were treated there, with six of them admitted. All were in stable condition, she said.

A Bridgeport Hospital spokesman said 26 people from the crash were treated there, with three of them admitted. One was in critical condition and two were in stable condition, he said. The other 23 were released.

The MTA operates the Metro-North Railroad, the second-largest commuter railroad in the nation. The Metro-North main lines ? the Hudson, Harlem, and New Haven ? run northward from New York City's Grand Central Terminal into suburban New York and Connecticut.

The last significant train collision involving Metro-North occurred in 1988 when a train engineer was killed in Mount Vernon, N.Y., when one train empty of passengers rear-ended another, railroad officials said.

___

Associated Press writers Michael Melia in Hartford, Conn., Susan Haigh in Fairfield, Conn., and Verena Dobnik in New York City contributed to this report.

Source: http://news.yahoo.com/probe-conn-train-crash-giving-way-cleanup-065132312.html

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Si Yajie and Liu Huixia dominate Women's 10m Synchro Platform ...

Si Yajie and Liu Huixia dominate Women?s 10m Synchro Platform ? Swimming news

Si Yajie and Liu Huixia of China dominated the final of Women?s 10m synchronised Platform on day one of the FINA/MIDEA Diving World Series 2013 in Guadalajara, Mexico on Friday, May 17.

The duo remained dominant over their opponents from the start and paved their way to the medal rostrum for gold medal. With their remarkable efforts, they remained comfortably ahead of their competitors on the scorecard and secured top spot on the podium.

They faced strong competition from their toughest pair and Malaysian divers, Pamg Pandelela Rinong and Leong Mun Yee, who gave them tough time in the first two rounds but eventually lost the score in the third round.

The Chinese and Malaysian pair remained head-to-head in the first two rounds securing 46.80 and 52.20 points respectively but the Malaysian pair dropped down on the scorecard in the third round.

With their continued efforts, the Chinese duo excelled on the scorecard in the third round by adding 80.10 points to their score. In contrast, the Malaysian team managed to get only 63.90 points.

Subsequently, Yajie and Huixia ended fourth and fifth rounds with a score of 80.64 and 76.80 points respectively. On the other hand, Rinong and Mun Yee managed to get 72.96 points in the last two rounds.

As a result, the Chinese pair secured gold medal of the event with a score of 336.54 points while the Malaysian pair occupied silver medal of the race by earning 308.83 points.

Following that, Couch Tonia and Barrow Sarah of Great Britain remained marginally away from overpowering their opponents and secured third place with a score of 304.38 points.

Fourth fastest spot of the race was obtained by Benfeito Meaghan and Filion Roseline of Mexico, who was almost two points away from the British duo by securing a total of 302.52 points.

Last position of the event was obtained by Orozco Alejandra and Mendoza Carolina of Mexico, who were unable to upset any of their competitors and ranked fifth on the scorecard with 292.56 points.

In addition, the position holders received medals and accolades at the prize distribution ceremony of the event.

Source: http://blogs.bettor.com/Si-Yajie-and-Liu-Huixia-dominate-Womens-10m-Synchro-Platform-Swimming-news-a215486

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$590M-plus Powerball: 1 winning ticket sold in Fla.

DES MOINES, Iowa (AP) ? It's all about the odds, and one lone ticket in Florida has beaten them all by matching each of the numbers drawn for the highest Powerball jackpot in history at an estimated $590.5 million, lottery officials said Sunday.

The single winner was sold at a supermarket in Zephyrhills, Fla., according to Florida Lottery executive Cindy O'Connell. She told The Associated Press by telephone that more details would be released later.

"This would be the sixth Florida Powerball winner and right now, it's the sole winner of the largest ever Powerball jackpot," O'Connell told AP. "We're delighted right now that we have the sole winner."

She said Florida has had more Powerball winners than any other state.

The winner was not immediately identified publicly and O'Connell did not give any indication just hours after Saturday's drawing whether anyone had already stepped forward with that winning ticket.

With four out of every five possible combinations of Powerball numbers in play, lottery executives said earlier that someone was almost certain to win the game's highest jackpot, a windfall of hundreds of millions of dollars ? and that's after taxes.

Saturday night's winning numbers were 10, 13, 14, 22 and 52, with a Powerball of 11.

Estimates had earlier put the jackpot at around $600 million. But Powerball's online site said Sunday that the jackpot had reached an estimated $590.5 million.

Terry Rich, CEO of the Iowa Lottery, initially confirmed that one Florida winning ticket had been sold. He told AP that following the Florida winner, the Powerball grand prize was being reset at an estimated jackpot of $40 million, or about $25.1 million cash value.

The chances of winning the prize were astronomically low: 1 in 175.2 million. That's how many different ways you can combine the numbers when you play. But lottery officials estimated that about 80 percent of those possible combinations had been purchased recently.

While the odds are low for any one individual or individuals, O'Connell said, the chance that one hits paydirt is what makes Powerball an "exciting game to play."

"There is just the chance that you will have the opportunity and Florida is a huge Powerball state. We have had more winners than any other state that participates in Powerball."

Such longshot odds didn't deter people across Powerball-playing states ? 43 plus Washington, D.C., and the U.S. Virgin Islands ? from lining up at gas stations and convenience stores Saturday for their chance at striking it filthy rich.

Calls by AP to the Publix supermarket outlet in Florida where the winning ticket was sold were not answered Sunday.

Elsewhere, Rich said, lottery officials reported 33 winning tickets for a $1,000,000 prize each were sold around 17 states, led by six tickets in New York. He said lotteries reported 2 winning tickets each for the $2,000,000 PowerPlay, one in New York and the other in South Carolina.

Before the drawing, there was a rush for tickets around the country.

At a mini market in the heart of Los Angeles' Chinatown, employees broke the steady stream of customers into two lines: One for Powerball ticket buyers and one for everybody else. Some people appeared to be looking for a little karma.

"We've had two winners over $10 million here over the years, so people in the neighborhood think this is the lucky store," employee Gordon Chan said as he replenished a stack of lottery tickets on a counter.

The world's largest jackpot was a $656 million Mega Millions jackpot in March 2012. If $600 million, the jackpot would currently include a $376.9 million cash option.

Clyde Barrow, a public policy professor at the University of Massachusetts-Dartmouth, specializes in the gaming industry. He said one of the key factors behind the ticket-buying frenzy is the size of the jackpot ? people are interested in the easy investment.

"Even though the odds are very low, the investment is very small," he said. "Two dollars gets you a chance."

That may be why Ed McCuen has a Powerball habit that's as regular as clockwork. The 57-year-old electrical contractor from Savannah, Ga., buys one ticket a week, regardless of the possible loot. It's a habit he didn't alter Saturday.

"You've got one shot in a gazillion or whatever," McCuen said, tucking his ticket in his pocket as he left a local convenience store. "You can't win unless you buy a ticket. But whether you buy one or 10 or 20, it's insignificant."

Seema Sharma doesn't seem to think so. The newsstand employee in Manhattan's Penn Station purchased $80 worth of tickets for herself. She also was selling tickets all morning at a steady pace, instructing buyers where to stand if they wanted machine-picked tickets or to choose their own numbers.

"I work very hard ? too hard ? and I want to get the money so I can finally relax," she said. "You never know."

___

Associated Press Radio Correspondent Julie Walker and AP writers Jeffrey Collins in Columbia, S.C., Betsy Blaney in Lubbock, Texas, Russ Bynum in Savannah, Ga., John Rogers in Los Angeles and Verena Dobnick in New York contributed to this report.

___

Follow Barbara Rodriguez at http://twitter.com/bcrodriguez .

Source: http://news.yahoo.com/590m-plus-powerball-1-winning-ticket-sold-fla-061647844.html

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Sunday, May 19, 2013

Pro-Assad hackers attack Financial Times

LONDON (Reuters) - The website and Twitter feed of British newspaper the Financial Times were hacked on Friday, apparently by the "Syrian Electronic Army", a group of online activists who say they support Syrian President Bashar al-Assad.

The group posted links on the newspaper's Twitter feed to a YouTube video, uploaded on Wednesday, which purports to show members of the al Qaeda-linked Nusra Front Syrian rebel group executing blindfolded and kneeling members of the Syrian army.

The video could not be independently verified.

Hacking attacks on verified Twitter accounts of media organizations have triggered urgent calls for the micro-blogging website to increase account security, particularly for news outlets.

"Various FT blogs and social media accounts have been compromised by hackers and we are working to resolve the issue as quickly as possible," a statement from the FT press office said. The paper is owned by Pearson Plc

Twitter was not immediately available for comment.

Stories on the FT's website had their headlines replaced by "Hacked By Syrian Electronic Army" and messages on its Twitter feed read: "Do you want to know the reality of the Syrian 'Rebels?'", followed by a link to the video.

The group has previously targeted the Twitter account of the BBC's weather service, and those of Human Rights Watch and French news service France 24.

In the most disruptive incident so far, someone took control of the Twitter feed of U.S. news agency the Associated Press last month and sent a false tweet about explosions at the White House that caused financial markets to plunge.

(Reporting by Mohammed Abbas, Kate Holton and Ben Berkowitz; Editing by Mark Trevelyan)

Source: http://news.yahoo.com/pro-assad-hackers-attack-uk-newspaper-fts-website-122913629.html

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As fireworks crackle, Beckham plays last home game

PARIS (AP) ? Never a stranger to the big stage, David Beckham was finally overwhelmed and reduced to tears as he went out in a burst of fireworks and cheers Saturday in his final home game for Paris Saint-Germain before retirement.

Fans chanted his name before the game, and they chanted some more when he was finished. There was an outpouring of hugs, cheers, song and congratulations ? from teammates, opponents and even former president Nicolas Sarkozy.

"To end my career in front of a crowd like that, with players like that, it's very special," Beckham said, adding that emotions had already started overpowering him before he was taken off.

"It started about 20 minutes before that, to be honest. I started thinking and then, you know, I couldn't concentrate by then, and it was difficult," he said. "You know, you try to hold the emotion back because it is what it is, but it's difficult."

There also was some soccer to be played. And Beckham, appointed captain for the game, was involved in two of his team's goals in a 3-1 victory over Brest.

He drew a roaring standing ovation and wiped away tears when he left in the 81st minute. As the match drew to a close, Beckham appeared to tire, putting his hands on his thighs as he leaned forward.

"I want to say thank you to everybody in Paris. To my teammates, to the staff, to the fans," Beckham told the fans after the game. "It's been very special to finish my career here. It could not have been any more special."

One after another, the players then walked out onto a makeshift podium in the middle of the field and thanked the crowd after the game had ended.

When it was Beckham's turn to climb onto the podium, the Beatles song 'Hello, Goodbye' rang out as the stadium's big screen beamed pictures of Beckham's short PSG career and flashed another message of thanks.

Draped in the English flag, Beckham sprinted onto the stage.

"Merci, Paris," he said. "I'm very sad to be leaving, but thank you."

PSG coach Carlo Ancelotti praised Beckham's impact on world football.

"He will miss the world of football because he showed a good image every time, really professional," Ancelotti said. "I think that he is sure that this decision was the right moment and we have to respect this. It was a fantastic evening for him. He will have a very good memory of this night."

When Beckham had gone off, the crowd, which included Sarkozy, rose as one and players trotted over to give him a hug. The players from Brest also understood the moment. Charlison Benschop, who had scored Brest's consolation goal a minute earlier, walked over to shake his hand.

With chants of "Dav-eed Beckham, Dav-eed Beckham" echoing, Beckham looked to be on the verge of tears. He applauded the crowd and blew a kiss to his family in the stands. There was time for one more hug ? this one a bit longer from coach Carlo Ancelotti ? before he sat on the bench, maybe for the last time.

"I spoke with David and told him that in my last (ever) game I scored two goals," Ancelotti joked. "I said to him 'Maybe tonight you'll score two goals' ? but maybe he didn't have my quality."

The former England captain announced Thursday he is retiring at the end of the season. Ancelotti added that it is unlikely Beckham will play in the final game of the season, away to Lorient on May 26, but that this has not been decided yet.

"I just feel that it's the right time. I feel that I've achieved everything that I could in my career. I wanted to go out as a champion," Beckham said. "I've finished my career in a team that has treated me like I've been here for 10 years.

Beckham has yet to say if he will play in PSG's last game, at Lorient on May 26.

"It's a historic moment," the stadium announcer intoned as Beckham was substituted. Not that the crowd of 44,983 needed a reminder.

As Beckham walked off slowly, applauding the fans, his hair uncharacteristically bedraggled, his mother, Sandra, wiped away a tear in the stands.

His replacement, Ezequiel Lavezzi, gave Beckham a big hug and then ruffled the fashion maven's hair. Beckham immediately swept it back into place.

After the final whistle, teammates hoisted Beckham off the ground and repeatedly tossed him in the air, putting a smile back on his face.

The celebrations kicked in as the lights were turned off, light sticks were held up and the crowd broke into song. The fireworks then flew into the night sky, accompanied by an 'Ole!' as each one went off.

"After 22 years of playing football I'm going to take a few months to enjoy time with my family," Beckham said, before adding that he still wants to stay involved with PSG. "It's been a very special place for me."

Before the game, the 38-year-old Englishman was given a rousing reception at Parc des Princes. Spectators broke into chants of "Merci, David" when his name was read over the stadium speaker.

PSG's players walked onto the field to a thunderous reception, with Nirvana's "Smells like Teen Spirit" reverberating. PSG right back Christophe Jallet dyed his hair in the blue, white and red of the French flag while the players all wore next season's team jerseys.

The game brought a stronger security presence, with about 150 riot police forming a ring inside the stadium in the second half. The show of force followed Monday night's riots at Trocadero plaza, where a celebration to mark the French title turned violent.

This was Beckham's 14th game and fifth start since joining PSG in a surprise move on the last day of the transfer window. He was appointed captain before the game.

PSG clinched the league title last weekend, making Beckham the first English player to win the championship in four countries after title success with Manchester United, Real Madrid and the Los Angeles Galaxy.

Beckham was involved in the opening goal in the seventh minute. His free kick found Clement Chantome, whose pass released Zlatan Ibrahimovic as he broke into the penalty area down the right side. Ibrahimovic struck the ball into the opposite corner.

Ibrahimovic almost scored a minute later when Beckham's superb long pass sent him through, but the imposing Swede hesitated between heading the ball over goalkeeper Alexis Thebaux or taking it past him. Theabaux snatched the ball from him.

Beckham set up the second goal in the 32nd with a corner kick from the left. Blaise Matuidi's poorly hit ball bounced into the ground and looped over Thebaux's outstretched arm. Ibrahimovic blasted in a free kick from 30 yards into the top left corner for the third goal, setting a personal record with his 29th league goal of the season.

Early in the second half, Beckham almost set up striker Kevin Gameiro with a curling cross from the right that the striker headed wide.

It would not be long before Beckham was gone, but the noise and the celebration and the fireworks still had a ways to go.

Source: http://news.yahoo.com/fireworks-crackle-beckham-plays-last-home-game-213444116.html

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